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Creators/Authors contains: "Brissette, Catherine A"

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  1. ; ; ; ; ; (, Journal of Physics D: Applied Physics)
    Abstract The Lyme disease spirocheteBorrelia burgdorfericauses an infection with diverse clinical outcomes, which can include arthritis as well as cardiac and neurological manifestations.B. burgdorferiexpresses different outer surface lipoproteins at different stages in its infectious cycle, many of which are adhesins. Utilizing atomic force microscopy (AFM), we obtained topography images and force–distance curves of wild-typeB. burgdorferiand mutant strains encoding different complements of surface lipoproteins. AFM data show that a reduced number of genome-encoded lipoproteins correlates with decreased binding probability, weakens unbinding force, and negatively affects cell elasticity. 
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